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Innovative natural solution to improve pigmentation and structural quality of gray hair

 Friday 09 October 2020

Published in IFSCC Magazine
in August 2020 (volume 23, No. 2), p. 91 - 96

Authors L. Verzeaux, R. Vyumvuhore, L. Marchand, S. Bordes, E. Aymard, and B. Closs

Hair graying is an obvious sign of aging, occurring with the loss of pigment production and deposition within the hair shafts. Numerous mechanisms, such as oxidative stress due to melanogenesis itself or environmental factors, induce this defect of pigmentation. If there are a lot of studies about graying at the hair follicle level, there is a lack of information about graying in hair shaft.

In a previous study, the molecular signature of graying hair was established by confocal Raman microspectroscopy. A specific signature in gray hair was described and new markers like lipid organization and protein conformation were identified.

Based on these discoveries, a natural active ingredient was developed to regulate hair graying. This active was able to stimulate melanin production and to detoxify gray hair through the innovative process of autophagy. Consequently, the natural active ingredient reduces H2O2 content in the hair shaft, as well as amino acids oxidation and improves the structural quality of the hair.

This active ingredient, commercialized under the name of AGREYNIST®, is anti-free radical and pro-pigmenting and enables greying hair to return to its natural color without the need of dyeing it.