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Highlighting of two distinct cellular behaviors in skin from aged healthy volunteers

 Monday 12 March 2018

Published in IFSCC Magazine
in December 2017, p. 215 - 220

Authors M. Laclaverie, L. Verzeaux, D. Boudier, V. Barruche, L. Marchand, S.  Bordes, B. Closs

If data are available to discriminate people appearing younger than their age, no in vitro study focuses on the cellular evidence explaining these observations. We investigated, from molecular to functional level, primary human skin cells isolated from aged healthy volunteers to highlight if distinct in vitro cellular behaviors could be observed. A transcriptomic analysisdemonstrated two transcriptomic signatures within skin cells from aged donors. At the functional level on monolayers and 3D reconstructed skin models, these two aged subpopulations displayed significant differences of migration and proliferation. Moreover, epidermis thickness, collagen I and hyaluronic acid expressions were also significantly different. For the first time in dermo-cosmetic research, we showed two distinct behaviors within primary aged skin cells: one with characteristics of aged skin cells as previously described in the literature and, very interestingly, the other one with a profile closer to young skin cells. These results provide a new sound scientific basis to explain the differences that could be observed between people aging well or not at the cutaneous level.

These research work supported the development of WELLAGYL®, the natural active ingredient meeting the concept of aging well.