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Published in IFSCC Magazine
in March 2017, p. 9 - 14

Authors M. Mangier, D. Boudier, M. Laclaverie, A. Bonnefoy, S. Bordes, B. Closs

Mitokines, recently identified genuine mitochondrial sentinels, are at the core of a cellular communication and defense strategy to combat stress. Increasing daily exposure to internal and/or external air pollution has harmful health impacts, in particular disruption of skin homeostasis. The skin is suffocated, dehydrated, dull and ages prematurely. Prohibitins are essential mitokines and widely studied in basic research, in particular in a pollution context related to a lung pathology. Nevertheless, no scientific data have established a link between mitokines and skin pollution. After having previously identified the aryl hydrocarbon receptor as a target of pollutants affecting the skin, a twostep in vitro modeling study was created and used to determine the role and regulation of mitokines in the skin. Initially, human keratinocytes were subjected to hypoxic stress (cobalt treatment) or exposed to pollutants (benzo[a]pyrene and particulate matter) and a significant reduction in prohibitin synthesis was found. After this, a mitokine-deficient reconstructed epidermis model revealed the major role of prohibitins during formation of a functional epidermal barrier, demonstrating how interesting restoring the skin mitokine capital is for future anti-pollution cosmetic strategies.