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SILAB decrypts the microbial signature of mature skin

The advanced research teams of the molecular biology pole of SILAB’s microbiota platform have sshown for the first time that the cutaneous microbiota of Caucasian women becomes imbalanced across aging.

This important discovery has just been published in the peer-reviewed Journal of Applied Microbiology [1].

[1] Romain Jugé, Pauline Rouaud-Tinguely, Josselin Breugnot, Katia Servaes, Christine Grimaldi, Marie-Paule Roth, Hélène Coppin, Brigitte Closs, Journal of Applied Microbiology, 2018 Sep; 125(3):907-916.

Metasequencing applied to mature skin

Facial skin samplings were taken from young and old Caucasian women and were analyzed by SILAB’s researchers using their high-tech MiSeq® tool. Bioinformatic analysis of the data showed that the distribution of the microbiota changes in the course of aging. Previous studies on Asian women had shown a change in the cutaneous microbiota in the course of aging. Nevertheless, given that each population has a different microbial signature with its own lifestyle, it was of interest to the scientific community to decrypt the imbalances of the age-related cutaneous microbiota specifically in Caucasian women stated Romain Jugé, SILAB’s R&D Project Leader.

Based on this scientific finding, future anti-aging cosmetic care products can contain active ingredients that restore the balance of the microbiota of mature skin.

ECOBIOTYS®, a cosmetic active ingredient that regulates the microbiota of mature skin

The results of these modeling studies in vivo led to the selection of panels of volunteers and the substantiation by metasequencing of ECOBIOTYS®, the first active ingredient bio-inspired by the high regulating capacity of floral nectar microbiota: the Nectarobiota®.

Obtained from the yeast Metschnikowia reukaufii, isolated from the nectar of the porcelain flower Hoya carnosa, ECOBIOTYS® specifically rebalances the distribution of bacterial communities of mature skin by strengthening the skin’s immune and mechanical barriers. The quality of the skin barrier its thereby improved and the complexion is enhanced.

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