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34 results for tag « publication »


Identification of miRNA-22-5p and miRNA-199a-5p as epigenetic targets to fight against environmental skin aging

 Wednesday 11 September 2019

The understanding of epigenetics mechanisms underlying transcriptomic modulations during skin stress has become a major priority for dermo-cosmetics research. In this context, SILAB aimed to study and correlate modulations in the miRNA profile (miRNome) with modifications of the mRNA profile (transcriptome) in human fibroblasts submitted to repetitive doses of solar simulated radiations (SSR) to induce irradiation-induced stress phenotype. SILAB performed an original screen of irradiation-regulated miRNAs in human fibroblasts that allowed the identification of two new miRNA-mRNA interactions mediating irradiation-induced stress.

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Structure-function relationship between a natural cosmetic active ingredient and the olfactory receptor OR2AT4

 Tuesday 26 March 2019

Although the olfactory receptor OR2AT4 has been described as involved in epidermal renewal, there is no data up to date about a cosmetic active ingredient able to activate this receptor. This research work thus revealed a natural molecule capable of binding to this OR2AT4 receptor in order to stimulate keratinocyte migration.

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Naturally mobilize the senses into the skin

 Tuesday 05 March 2019

Stimulated by beauty rituals, the senses can also be awakened into the skin through recently observed biological activity. The discovery of sensory receptors in the epidermis, in particular olfactory and taste receptors, opens up new prospects for the regeneration of skin tissue in aging conditions.

Based on strong scientific expertise (in vitro modeling study, metabolomic study, in silico molecular modeling), SILAB developed a cosmetic natural active ingredient imbued with sensoriality targeting epidermal regeneration. It is derived from a co-product of coconut, a tropical fruit with a unique sensory profile.

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SILAB Research published in Experimental Dermatology

 Thursday 21 February 2019

In partnership with Prof. Peter Elias' research team at the University of California San Francisco (UCSF), SILAB Advanced Research unravels a yet unidentified biological cooperation: the capacity of skin cells to activate a local immune response.

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Lipid organization in xerosis: the key of the problem?

 Thursday 24 January 2019

Although xerosis is a common skin disorder among the population, there is no in vivo global study focusing on xerotic skin. Hence, the objective of this study was to characterize xerotic skin from the surface to the molecular scale with in vivo and noninvasive approaches.

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